A very, very, very, very, very, very, etc., small amount.

Posted on: Mon, 03/24/2003 - 3:40pm
MommaBear's picture
Offline
Joined: 09/23/2002 - 09:00

[url="http://www.scripps.edu/~davess/past.html"]http://www.scripps.edu/~davess/past.html[/url]

Disclaimer: I do not guarantee the accuracy or content of the link in this post.

Posted on: Tue, 03/25/2003 - 1:29am
Corvallis Mom's picture
Offline
Joined: 05/22/2001 - 09:00

Maybe I can clarify for y'all:
This link explains in part why pn proteins (one of them, anyway [img]http://uumor.pair.com/nutalle2/peanutallergy/wink.gif[/img] ) are so different than other allergenic proteins- that is, why they are so efficient at eliciting severe allergic responses. The link describes the structural conformation of the protein as having a nearly perfect size and shape to interact with IgE (you know, the Y-shaped antibodies which PA people have in their bloodstream) for the protein... and that the fact that it has three identical sections exactly 50A apart means that once a single part of the protein has interacted with one side of the IgE, it is almost a guarantee that the other "side" of the IgE will successfully attach to the protein and be able to interact with a mast cell receptor. The 50 angstrom distance holds the other parts of the protein in exactly the right way to cause additional interaction is the gist of the linked page.
(For those who are curious, this is called the "chelate effect" (Kee-Late) in chemistry circles, and it increases interactions by 5x to 10x quite often.) This is a lovely explanation of why amounts of PN protein can be an order of magnitude smaller than, say, egg protein and yet still elicit severe reactions in the allergic.
Hope this helps! [img]http://uumor.pair.com/nutalle2/peanutallergy/smile.gif[/img]

Posted on: Tue, 03/25/2003 - 3:45am
MommaBear's picture
Offline
Joined: 09/23/2002 - 09:00

[img]http://uumor.pair.com/nutalle2/peanutallergy/biggrin.gif[/img]

Posted on: Wed, 03/26/2003 - 2:42pm
teacher's picture
Offline
Joined: 11/02/2000 - 09:00

I am NOT scientifically-minded whatsoever, so maybe this is a crazy question, but I'll ask anyway.
Doesn't the answer to these problems, then, lie in either changing the peanut protein or changing your IgE?? Is there some way to do one or the other? Or both?

Posted on: Wed, 03/26/2003 - 3:13pm
Corvallis Mom's picture
Offline
Joined: 05/22/2001 - 09:00

Could be an approach... IgE isn't a realistic "target" this way because the immune system is somehow programmed by sensitization to make IgE a certain way... any way of effecting this mechanism is likely to have serious immune effects in treated persons (probably not so good).
As far as modification of pn proteins, this is an area of current research. Two big problems.
1. The Ara h1 protein noted in the link above is only one of at least six identified allergenic proteins in the peanut, so you might have to modify several different proteins.
2. Without belaboring the point too much, this is genetic engineering. General public isn't even comfortable with the irradiation of meat products, so it isn't too likely that the average pn eating consumer is going to be real happy to sign their kids up for this.
[img]http://uumor.pair.com/nutalle2/peanutallergy/frown.gif[/img]

Posted on: Fri, 03/28/2003 - 10:16pm
river's picture
Offline
Joined: 07/15/1999 - 09:00

Corvallis Mom,
Maybe you know the answer to this question:
Doctor's talk about a developing immune system. Does that mean that the immune system is more sensitive in babies and small children? It seems like it is constantly developing and changing your whole life, so I don't quite understand the difference between an adult and a child.

Posted on: Sun, 03/30/2003 - 9:15am
Corvallis Mom's picture
Offline
Joined: 05/22/2001 - 09:00

river, I am not sure that physicians really know for sure either- I [i]think[/i] this theory is empirically based more than anything else. Obviously, anyone can develop allergies of any kind at any point in one's life, but there are some particularly vulnerable times too. (Pregnancy and post-partum for atopic women, for example.) This seems to be especially true for people with atopic genes- during the first 2-5 years of life, the immune system is still learning how to respond to the world, and it is more likely to learn an inappropriate response to pretty much anything it encounters. Once this learning period is over with, the immune system becomes less "plastic"- that is, it seems to remember what to respond to and what not to respond to, and this is why children who catch communicable diseases as very young infants can often catch the illnesses again in later, even though most people's immune systems "remember" them later. (I hope that made sense!) It is also why a lot of our allergists regard the age of 3 (or 4 or 5 [img]http://uumor.pair.com/nutalle2/peanutallergy/wink.gif[/img] ) as "magical" because children frequently outgrow allergies by about that age (or develop new ones around then [img]http://uumor.pair.com/nutalle2/peanutallergy/frown.gif[/img] ) What you see allergy-wise beyond that period tends to be lifelong. (So the percentage of allergic children at 8-10 years old is very similar to the adult population, though it is around half what it is in toddlers.)
It seems that non-atopic children do this "maturing" more rapidly than highly atopic ones...
Remember, this is based on observation, inference, and reading- it isn't medical advice by any means!!
What this also means for me *personally* (aside from the obvious conclusion that atopic families really really ought to be cautioned about allergy triggers) is that I don't pay a lot of attention to the comfort zone of anyone who hasn't had any allergic responses since those preschool years... I have to wonder if they haven't merely been careful and lucky so much as they have actually outgrown the allergy and don't know it. Lots of people don't bother retesting so they might not know. (JMO.) I hope this doesn't offend anyone- it is only my opinion.

Posted on: Sun, 02/15/2004 - 12:00pm
MommaBear's picture
Offline
Joined: 09/23/2002 - 09:00

reraising.

Posted on: Mon, 02/16/2004 - 3:32pm
nikky's picture
Offline
Joined: 11/14/2000 - 09:00

Thanks for raising MB. This was very interesting!

Posted on: Mon, 04/12/2004 - 9:21pm
MommaBear's picture
Offline
Joined: 09/23/2002 - 09:00

Quote:Originally posted by Corvallis Mom:
[b]
1. The Ara h1 protein noted in the link above is only one of at least six identified allergenic proteins in the peanut, so you might have to modify several different proteins.
[/b]
Hmmmmmmmmmmmm. I'd like to know more about this protein as well as the others.

Posted on: Tue, 04/13/2004 - 9:25am
PeteFerraro's picture
Offline
Joined: 07/10/2001 - 09:00

Quote:Originally posted by Corvallis Mom:
[b]isn't a realistic "target" this way because the immune system is somehow programmed by sensitization to make IgE a certain way... any way of effecting this mechanism is likely to have serious immune effects in treated persons (probably not so good).
[/b]
Are you implying that drugs like Xolair may not be a good idea?
------------------
Pete Ferraro
[url="http://www.FerraroFamily.org"]http://www.FerraroFamily.org[/url]

Posted on: Tue, 04/13/2004 - 9:31am
PeteFerraro's picture
Offline
Joined: 07/10/2001 - 09:00

I googled on: [b]"Ara h1"[/b]
I found: [url="http://www.ars.usda.gov/research/projects/projects.htm?ACCN_NO=404834&fy=2002"]http://www.ars.usda.gov/research/projects/projects.htm?ACCN_NO=404834&fy=2002[/url]
It describes attempts to create a hypoallergenic peanut. This study has been raised before in other threads.
At least someone is thinking about the problem. Two seperate groups attacking the problem are better than one.
------------------
Pete Ferraro
[url="http://www.FerraroFamily.org"]www.FerraroFamily.org[/url]
[This message has been edited by PeteFerraro (edited April 13, 2004).]

Posted on: Mon, 08/30/2004 - 12:11am
MommaBear's picture
Offline
Joined: 09/23/2002 - 09:00

reraising. Needed to put it in *my file* for a meeting this afternoon. [img]http://uumor.pair.com/nutalle2/peanutallergy/biggrin.gif[/img]

More Community Posts

Peanut Free and Nut Free Community

create a new community post
Latest Post by penelope Mon, 10/14/2019 - 12:56pm
Comments: 0
Latest Post by penelope Mon, 10/14/2019 - 12:52pm
Comments: 1
Latest Post by Italia38 Tue, 10/08/2019 - 12:19pm
Comments: 3
Latest Post by Italia38 Tue, 10/08/2019 - 12:18pm
Comments: 1
Latest Post by penelope Mon, 10/07/2019 - 7:19pm
Comments: 2
Latest Post by penelope Mon, 10/07/2019 - 7:16pm
Comments: 10
Latest Post by penelope Mon, 10/07/2019 - 7:13pm
Comments: 13
Latest Post by penelope Mon, 10/07/2019 - 7:10pm
Comments: 9
Latest Post by mom2two Mon, 09/16/2019 - 1:03pm
Comments: 18
Latest Post by desmond Mon, 09/16/2019 - 1:00pm
Comments: 1
Latest Post by desmond Mon, 09/16/2019 - 12:58pm
Comments: 19
Latest Post by TeddyCan Mon, 09/09/2019 - 4:32pm
Comments: 10
Latest Post by DTurner Mon, 09/09/2019 - 4:31pm
Comments: 5
Latest Post by B.M.18 Mon, 09/09/2019 - 4:30pm
Comments: 3
Latest Post by abolitionist146 Mon, 09/09/2019 - 4:28pm
Comments: 2
Latest Post by nutfreenyc Mon, 09/09/2019 - 4:19pm
Comments: 4
Latest Post by AllergicTeen2 Mon, 09/09/2019 - 4:18pm
Comments: 2
Latest Post by PeanutAllergy.com Fri, 09/06/2019 - 1:52pm
Comments: 1

More Articles

You might have wondered if small amounts of an ingredient can be added to a food product without being declared on the food’s label. The FDA...

Is it possible to eat your way to a food allergy cure? Scientists think it’s...

There are many reasons why you may want to substitute almond flour for wheat flour in recipes. Of course, if you have a...

Not all oils are created equal. Some oils are high in saturated fats or in trans-fatty acids – not good for general health. Some are partially...

It may never be safe to begin feeding peanut butter to your baby or toddler if you have peanut allergies in your family. If either parent or one...

More Articles

More Articles

What is a peanut allergy? It is a reaction that occurs in the body after eating peanuts or peanut...

For those with severe food allergies, flying can be a stressful process. Here are...

Approximately one out of 13 children under age 18 are allergic to at least one food, though many of them will outgrow their allergy by the age of...

Fact 1: Over a third of food allergy reactions happen after the first known oral...

The reason why some people are affected by allergies while others are not begins in their genes. Allergies are passed down from generation to...

Here’s a tip that might someday save your life, or that of a loved one: two to four times a year, review the proper way to use your epinephrine...

Lactose intolerance is the inability to process lactose, a sugar found in milk, caused by the lack of a needed enzyme. Those with lactose...

Food Allergen Labeling and Consumer Protection Act (FALCPA)

An important part of peanut allergy awareness was enacted on January 1, 2006...

Tomato allergies are very rare. They are a "type 1 allergy," which means a contact allergy. When a person with this type of allergy touches a...

Milk allergies are becoming more common, especially in babies and small children. There is some confusion about what is an allergic reaction and...

Recognizing food allergy in babies or toddlers is not always easy, but there are specific risk factors and signs that parents and other caregivers...

Burlap bags are often used to store and ship coffee beans, potatoes, rice, seeds, nuts, and peanuts. They can be one of the disguised...

People with pollen allergies need to stay away from some foods. If you have allergic rhinitis in the spring or fall, you may not realize that you...

Of course, everyone knows that if you have a peanut allergy that you should avoid peanuts, peanut butter, peanut butter cookies and foods that...

Eating at a nut-free lunch table in school is a safety precaution that causes some students to feel isolated from their peers. Unfortunately,...