Xolair question?

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Does anyone know where Xolair stands with being used in Canada? When my son's PA was diagnosed in April 04 our allergist said that the shot should be available in a couple of years. Thanks

On Apr 26, 2005

I don't know about Canada, I'm in the US, but I must say I don't trust any date until it's on the shelf. I was told within 3 years in late 1999.

On Apr 29, 2005

in the UK St marys hos is starting a trial on this, but have no plans as yet for it to be prescribed , 2-5yrs mentioned. Who knows?!! sarah

On May 11, 2005

Just took my son to the allergist today for a chat about...yet another new allergy (apples) not just oral allergy syndrome...real bona fide apple allergy, CAP level 3. Anyway...our allergist said Dr. Sampson is currently doing a Xolair trial in NYC -- "A Phase II, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled, Oral Food Challenge Trial of Xolair (Omalizumab) in Peanut Allergy", and he gave us all the paperwork to possibly have my son enrolled in this - he thinks he fits all the 'criteria' for a candidate. Anyway... I'm at the point of researching Xolair, and deciding if this is something we want to venture into. Had a bad, bad, bad (oh - and did I say bad?) response with seasonal allergy immunotherapy with him, so I'm really reluctant to venture into such a thing again, as is my son...who does not want to be a "science experiment." Anyway... allergist says....first step is to do the bloodwork to determine my son's overall IgE. If it is too high...he does not qualify for this study/trials. Anyway... I have the whole list of criteria that would 'disqualify' one from such a study, and the pre-requs that have to be met, if anyone is interested. And if anyone is currently in this NYC trial ... I'd be most curious to hear how it is going. What I don't like, off the start....is that they have to "induce" or "challenge" before the trial...which to me, means, set off a reaction first....before any treatment.

On May 12, 2005

Hi Laura, I've been in Dr. Sampson's tanox study for almost 4 years. The drug mechanism and study protocol for Xolair is very similar to that of tanox. I've extensively posted about my experiences (both good and bad) on this board. Here are a few links, but for a full listing you can do a search with tanox or xolair as the search words: [url="http://uumor.pair.com/nutalle2/peanutallergy/Forum1/HTML/003822.html"]http://uumor.pair.com/nutalle2/peanutallergy/Forum1/HTML/003822.html[/url] [url="http://uumor.pair.com/nutalle2/peanutallergy/Forum1/HTML/004743.html"]http://uumor.pair.com/nutalle2/peanutallergy/Forum1/HTML/004743.html[/url] [url="http://uumor.pair.com/nutalle2/peanutallergy/Forum3/HTML/001101.html"]http://uumor.pair.com/nutalle2/peanutallergy/Forum3/HTML/001101.html[/url] [url="http://uumor.pair.com/nutalle2/peanutallergy/Forum1/HTML/006057.html"]http://uumor.pair.com/nutalle2/peanutallergy/Forum1/HTML/006057.html[/url] I also wanted to add that I also had a really hard time with environmental immunotherapy (I went into anaphylaxis). However, anti-IgE therapy works on a completely different mechanism then immunotherapy. With immunotherapy, you are injected with actual protein that you are allergic to, with the hope the the body will be able to slowing increase tolerance. However, anti-IgE therapy binds to one of the primary allergic causing components of the immune system (Ige)therefore preventing the IgE from binding to proteins of allergens. Anti-IgE has systemic effects (and is not peanut specific) so it may improve your son's environmental and other food allergies. Please feel free to email off boards if you have more questions. Good luck with your decision. Allison

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