Vaccine

Posted on: Mon, 03/29/1999 - 10:38am
Greg's picture
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Here is a link to a recent story about a vaccine for peanut allergies. Nice to know at least there are some people out there working on this problem
[url="http://www.msnbc.com/news/254339.asp"]http://www.msnbc.com/news/254339.asp[/url]

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Posted on: Mon, 03/29/1999 - 12:46pm
Anonymous's picture
Anonymous (not verified)

Greg, thanks for the link. I am also glad someone is working on a vaccine but, I have to admit, when I heard a vaccine was in the works, I thought it was for peanut allergic people, not for people who had not already been exposed to the peanut protein. Don't get me wrong, if we can avoid someone new from getting this allergy, that would be wonderful, BUT, as the article mentioned and I quote "the researchers stressed that the study involved mice who had never been exposed to peanuts. Whether the vaccine is effective in those who have already developed peanut allergy, or in people, is unclear."
Also as quoted in the last paragraph of the article - "if the vaccine containing the gene for the peanut protein is given to a mouse that has already developed peanut allergy, the dose may trigger the onset of symptoms."
It is hopeful that a vaccine will be available for EVERYONE in time but I must admit that last paragraph scares me!

Posted on: Mon, 03/29/1999 - 1:34pm
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Joined: 02/03/1999 - 09:00

I don't know whether to be encouraged that they've made progress, or scared because the progress they've made so far won't help my peanut-allergic child. Connie -- I too was concerned about the very things you were.
This part gives me some hope:
"The research is preliminary, but it does offer hope that it may be feasible in the near future to use a vaccine to treat peanut allergy in people, according to Dr. Wesley Burks, a professor of pediatrics at Arkansas Children

Posted on: Tue, 03/30/1999 - 8:45am
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Joined: 01/22/1999 - 09:00

oops
[This message has been edited by brenda (edited March 30, 1999).]

Posted on: Tue, 03/30/1999 - 8:47am
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i messed it up again
[This message has been edited by brenda (edited March 30, 1999).]

Posted on: Tue, 03/30/1999 - 8:48am
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Here is another site about the vaccine that had a little bit more description.
[url="http://biz.yahoo.com/rf/990330/1w.html"]http://biz.yahoo.com/rf/990330/1w.html[/url]

Posted on: Tue, 03/30/1999 - 12:12pm
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Joined: 05/28/2009 - 16:42

I believe some of the top research efforts to help those afflicted with the peanut allergy and some other food allergies are being carried out by Mt. Sinai NY and University of Arkansas.
I had an earlier post with the following site
[url="http://www.uams.edu/biochem/Faculty/GBANNON.HTM"]www.uams.edu/biochem/Faculty/GBANNON.HTM[/url] Dr. A. Wesley Burks out of University of Arkansas and Dr.
Hugh Sampson out of Mt. Sinai New York are really closing in on this severe allergy. I was fortunate enough to talk with
Dr. Burks. He was optimistic about the research work for densensitizing the peanut allergic population. I also spoke to Dr. Sicherer (who works with Dr. Sampson) at the 1998 Food Allergy Network Conference - I asked him if he agreed with Dr. Burks' view and time frame for a vaccine - HE DID!
The Mt. Sinai Site [url="http://www.mssm.edu/immunobiol/FacultyFrame.html"]www.mssm.edu/immunobiol/FacultyFrame.html[/url] click on Dr. Sampson's name.
The Jaffe Family Foundation has been a major force in the research efforts led by Dr. Sampson. The Institute was
established in 1997 by an endowment gift from the Jaffe Family Foundation. Their program description notes that clinical
research is also an important part of the Institute's work. With the information gathered by the clinical research, the Institute seeks to discover improved treatment options.
I personally am very appreciative of the Jaffe Family and the work they have funded. I do feel that with the generosity of this
family and the expertise and focus given by Dr. Sampson and Dr. Burks to the peanut allergy, we all may see the day when
there is a vaccine to stop life threatening peanut allergic reactions.
I would suggest that you enroll in FAN's upcoming Spring Conferences for 1999 - There will be a report on research efforts/vaccine efforts.
In addition, you can review the abstracts on peanut allergy research findings and other allergy abstracts through the AAAAAI. Their site is [url="http://www.aaaai.org/default.htm"]http://www.aaaai.org/default.htm[/url]
[This message has been edited by Mary (edited March 30, 1999).]

Posted on: Wed, 03/31/1999 - 2:56am
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I just read the article posted by Brenda and am more than a little concerned about where things are going. Here's part of the article:
*******
[...]
``We chose to use a preventive vaccine model instead of a treatment model,'' they wrote.
A treatment or therapeutic vaccine is used to treat existing disease, or in this case, existing allergy, as opposed to trying to prevent infection or allergic reaction in the first place.
A vaccine might not work in someone who is already allergic to peanuts, they said.
``However, given that the only treatment of food allergy is complete avoidance of all allergen-containing food products and often involves aggressive emergency treatments, pre-immunization may be a viable therapeutic model,'' they wrote.
********************
What good is a preventative vaccine going to do for people who already have the allergy?
Do they think all parents will go for vaccinating their kids against a possible peanut allergy? Some will, but I bet a lot won't because they might be afraid their kids will get the allergy if they're innoculated.
I would like them to work on something that will help my son, who has the allergy. Am I misunderstanding something? Is this just the first step in their research, or is this the solution they've decided to work on?
--Tracy

Posted on: Wed, 03/31/1999 - 3:14am
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Joined: 01/16/1999 - 09:00

One slightly encouraging fact found in the article is that the mice that were tested were bred to be allergic to peanuts, which is more akin to a person already having the allergy as opposed to giving the vaccine to someone who never had the allergy. I suppose this 'might' mean that in the future it may work for someone who already has a peanut allergy. Just don't expect me to have my daughter first in line to try it,maybe way down the line when if it shown to be safe, but not after many,many,many tests.
Just as a curious side note, I noticed the material used to deliver the drug was created from the shells of crustaceans. I wonder if this could have implications for those with severe shellfish allergies?? Being personally clueless to shellfish allergies I was just wondering.

Posted on: Wed, 03/31/1999 - 5:16am
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Joined: 03/10/1999 - 09:00

Hi All!
I spoke with a woman last week (she called me as a result of the article on my son in "Child" Magazine). She works on the fund raising for Dr. Sampson and the Mt. Sinai vaccine. She told me their vaccine CAN be used on those already allergic to peanuts! While it won't eliminate allergic symptoms entirely, it will prevent anaphalyxis in those already allergic. I couldn't believe what I was hearing! She said this vaccine is going into clinical trials in adults in six months, and then children will follow. Hopefully, it will be available to the public in the next five years. Has anyone else heard this one? I hope it's true!

Posted on: Wed, 03/31/1999 - 6:39am
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Joined: 03/14/1999 - 09:00

Yes. We had a lot of information also at one time on the research into this area by, I believe somebody at Cambridge. I believe the clinical trials were being done in Poland. (I also believe that the first volunteer ceased to exist. Please feel free to correct me at any point...I have been trying to relocate one of the sources of this information. I can't find anything about it. Funny that you should mention Dr. Sampson. I just E mailed him earlier today asking for the most current information on this and any other studies going on. Will let you know if I hear anything (if I don't I will ask one of his colleages to contact him again).

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