New discovery may lead to new medications....

Posted on: Wed, 10/20/2004 - 10:10am
tcperrine's picture
Joined: 03/01/2002 - 09:00


Public release date: 20-Oct-2004
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Contact: Sarah L. White, Ph.D.
Ludwig Institute for Cancer Research

p110 delta: A key player in the allergic response

Potential new target for drug development
(London - October 21) -- The suffering of millions of people with allergies could one day be eased thanks to new research from UK investigators. Findings from the University College London Branch of the Ludwig Institute for Cancer Research (LICR), published in this week's Nature, detail how inactivating a key signalling molecule called p110delta reduced the effect of allergies on mice.
Allergies are essentially inappropriate responses by the immune system to allergens such as pollen, dust, insects and animals. This results in the activation of immune cells, called mast cells, which release inflammatory agents, leading to the symptoms so many of us know so well: runny noses, itching eyes, coughing, skin rashes and wheezing.

Dr. Bart Vanhaesebroeck and his team at LICR, together with collaborators from Novartis Respiratory Disease Centre headed by Dr Peter Finan, found that inactivating p110delta in mast cells substantially reduces the allergic response seen in mice. In mice lacking the gene for p110delta, the allergic response was reduced substantially; in normal mice that had been treated with an experimental drug inhibiting p110delta, the allergic response was stopped completely.

Allergies have increased dramatically over the past 20 years, and new treatments are clearly needed. Experts estimate that, in the UK alone, 1 in 3 people will suffer from some form of allergy during their lifetime; some 9 million people suffer from hay fever, 6 million from eczema and 5 million from asthma each year. In the most extreme circumstances, an allergic reaction can be life-threatening or even fatal. This is commonly seen in peanut and drug allergies.

According to Mr. Khaled Ali, the lead author of the study, current therapies to treat allergies are mainly non-specific, targeting the symptoms of allergy rather than targeting what is actually happening in the mast cells themselves. "It is hoped that by targeting p110delta, we can directly stop mast cell activation and, in doing so, help end the misery they bring to many sufferers."

"We have to remember though that mice are not the same as humans," cautions Dr Vanhaesebroeck. "Our work points towards a promising future for developing inhibitors for allergic conditions, but we are still a long way from developing a drug for human patients." The LICR group's research efforts are also focused on their findings that p110delta could also play a role in certain tumours, like leukemia, and that targeting the p110delta pathway may one day also be useful in the treatment of cancer.

This study was conducted by researchers from the University College Branch of the Ludwig Institute for Cancer Research, London, the Novartis Respiratory Research Centre Horsham, Frimorfo Ltd, the Department of Biochemistry of the University of Dundee, the Department of Biochemistry and Molecular Biology of University College London, and the Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health.

Posted on: Wed, 10/20/2004 - 10:20am
Danielle's picture
Joined: 04/08/2003 - 09:00

Thx for posting.
I am always happier when I see someone has posted in the research section.
Interesting info and I do really beleive that

Posted on: Wed, 10/20/2004 - 11:16pm
Lovey's picture
Joined: 03/22/2004 - 09:00

[quote]Originally posted by tcperrine:
"We have to remember though that mice are not the same as humans," cautions Dr Vanhaesebroeck. "Our work points towards a promising future for developing inhibitors for allergic conditions, but we are still a long way from developing a drug for human patients."
I'm very happy to see that not only is this research happening but that Dr. Vanhaesebroeck has the professionalism and integrity to not raise false hope but instead to be honest about the nature of this very early research.

Posted on: Wed, 10/20/2004 - 11:48pm
crazydaisy's picture
Joined: 11/14/2003 - 09:00

tcperrine,Thank You!
More hope.
The Daisy Thanks You

Posted on: Thu, 10/21/2004 - 2:59am
Suzy Q's picture
Joined: 05/20/2004 - 09:00

I would just like to say THANK YOU to those who are constantly researching articles, links, legislation, etc. to include on this site. If not, I would never see most of these and have a lot less information than I do.
This type of information gives me so much hope for the future that my son and others won't always have to live in fear because of food. We've just passed our 1 year mark of dealing with the allergy and have settled into a somewhat comfortable routine, but I still have quite a lot of anxiety at times.

Posted on: Mon, 11/08/2004 - 4:51am
Laura Petrauskas's picture
Joined: 11/08/2004 - 09:00

I am a mother of 5year old twins, both having asthma and one being peanut fatal. I'm so excited, I have been using some nonevasive technologis on my children and am having miraculous results. My son was so sick at this time last year the doctor had him tested systic fibrosis (neg.) but that gives you an idea of how sick he was. He was also re-tested for his peanut allergy recently, skin test 1st which showed no signs of the allergy, but I was informed that the test was working properly because of the positive site had a reaction. this absolutely made no sence to me, because previous test he had turned red from his hairline down to his but and up around his side, and were the site was it raised up and branched out into long fingers, the doctor had his blood drawn and had it sent to Mayo Clinic were it showed that he went from a peanut fatal down two notches to a severe.In my heart I know what I have been doing has helped my children tremendously. Both children have only been sick a couple of times this year compared to being sick all the time on all kinds of medications which then gave them adverse side effects none of which were very nice. I have spoke to a scientist from Duke University of Research and they are as excited about the outcome of my childrens health situation as I am and are trying to get proposals together to submit to a few organizations to get research done in this feild. I also should mention my son grew a few inches after being at a standstill from the steriods, he has lost a couple of pounds and he is even sitting with all the other children this year eating lunch which he couldn't even walk past the room last year without breaking out in hives on his face. He actually has some normalcy back into his life. Don't get me wrong he cannot eat any peanut products but he is defintely on a much better rode than a year ago. adverse

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