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Great news on peanut allergy research! - Peanut Allergy Information

Great news on peanut allergy research!

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Did anyone see this week's New England Journal of Medicine? Apparently the latest results on peanut allergy looks promising. Here's the link to the Reuters story (haven't seen the actual NEJM article yet):

[url="http://story.news.yahoo.com/news?tmpl=story2&cid=570&e=6&u=/nm/20030310/sc_nm/health_peanuts_dc"]http://story.news.yahoo.com/news?tmpl=story2&cid=570&e=6&u=/nm/20030310/sc_nm/health_peanuts_dc[/url]

On Mar 10, 2003

Thank you for posting this.

Take care

Katiee

On Mar 10, 2003

Wonderful! No, it's not a cure, but I felt a strange sense of happiness after reading it! I know it's not here yet, but I love the feeling of hope it brings to me.

Thanks for posting the link.

Sue in Sunny Arizona

On Mar 10, 2003

Please see my comments on the Research board. The articles will be published on the 13th.

Troy

On Mar 10, 2003

I'm not sure if this is the same story, but I've just heard that Global News (in Canada) is supposed to have a story about a breakthrough treatment for "life-threatening peanut allergies" at 5:30 pm EST. I'm sure Global affiliate stations across Canada will also carry the story later in the evening.

Carolyn

On Mar 10, 2003

Interesting article. Although when I read:

Quote:

[i][b] "Peanuts can be used to thicken brown gravy, or in pie crusts or even to hold an egg roll together," said Anne Munoz-Furlong, founder of the non-profit awareness group Food Allergy & Anaphylaxis Network[/i][/b]

It sounded pretty scary too. The idea that I order roast beef in a restaurant and the gravy was thickened with peanut, or I order a slice of apple pie (and the waiter says it is peanut free) but the crust contained peanuts. I once read of someone in the USA who died after eating chili as it has been thickened with a bit of peanut butter.

Fortunately I think this is quite rare (I hope!) but you always have to be on your guard with this allergy.

[This message has been edited by erik (edited March 10, 2003).]

On Mar 10, 2003

I don't know how I really feel about this. I suddenly have people telling me "oh, now you won't have to worry it is cured" Which of course we all know isn't the case w/ this vaccination. It is still several years away and they already mention the cost. When my son was a Preemie he had a monthly shot of Synagis that was about 1600/month...wonder if this shot would be the same and if insurance would or wouldn't cover it. Don't mean to be a downer, but sometimes I wish they wouldn't make is sound like suddenly their is a fail proof cure that everyone can use...I guess I just don't want to get too excited.

On Mar 10, 2003

I posted the links to the NEJM articles on peanut allergy on the Research Board under the thread "PA Vaccine Update".

On Mar 10, 2003

Quote:

Originally posted by erik: [b]I once read of someone in the USA who died after eating chili as it has been thickened with a bit of peanut butter[/b]

This story is true, and the reason I know it is that the young woman who died from the PB-laced chili was a student in college with me in the early 1980s. She was at a local restaurant about 50 feet from my dorm room. It was the first time I heard of fatal food allergies, and in part it's her story that made me keep my son away from peanuts until he was (nearly) 3, even though we had no food allergies in our family (at the time). (He is PA/TNA, but maybe his allergies would be worse if we hadn't waited.)

What a sad, sad story it was to lose an academically high achieving and athletic young woman to a secret ingredient.

Debbie

On Mar 10, 2003

Actually, this may be even better news:

[url="http://www.post-gazette.com/healthscience/20030310allergy0310p3.asp"]http://www.post-gazette.com/healthscience/20030310allergy0310p3.asp[/url]

On Mar 10, 2003

One of our news stations here in Chicago had a breif portion on peanut allergy and future treatments.

Did anyone else find it unusual that multiple channels had stories on similiar topics in one day that are not usually discussed?

On Mar 10, 2003

Mommabear, It usually happens when a study will be published in the New England Journal of Medicine or other major journal. The Associated Press picks up the story and thus it is transmitted to every news organization around the world... -Cindia

On Mar 11, 2003

Welcome Pete!

That [b]does[/b] sound amazingly good, especially since they could potentially alter the immune response without compromising it in any way.

Thanks for the great link!

Amy

On Mar 11, 2003

Quote:

Originally posted by Cindia: [b]Mommabear, It usually happens when a study will be published in the New England Journal of Medicine or other major journal. The Associated Press picks up the story and thus it is transmitted to every news organization around the world... -Cindia[/b]

Thank you! I figured it probably has something to do with a "release" of some kind. [img]http://uumor.pair.com/nutalle2/peanutallergy/smile.gif[/img]

On Mar 11, 2003

PA and future treatmenrs is front-page news in the Montreal Gazette today.

Nice to have some good press for a change...

On Mar 11, 2003

Hi,

My PA hairdresser had a severe reaction after eating at a popular Mexican restaurant chain here in AZ. Oops, sorry I forgot to mention that it was the red chile sauce.

As for the issue, it sounds hopeful. Two things though (could be more):

A.) Until I see written documentation that this drug has been tested on children, determined to be safe & dosage requirements have been adequately determined will I consider it for my dd. Something tells me that the people that are participating in this experiment are only adults.

Does anyone here have their child or know of anyone whose child is involved in this experimental treatment?

B.) My dd is almost 9 years old & has been reaction free for about 7 years, therefore she may not want to have monthly injections. And if she decides she wants to have the injections, she may want to experiment w/eating PB, how much PB is too much, then if she likes it we're onto learning a whole new set of rules, etc, etc, etc.

Sorry if anyone thinks I'm trying to be a downer.

[This message has been edited by LisaMcDowell (edited March 11, 2003).]

On Mar 11, 2003

These findings have not only come out with lots of publicity from the NEJM, but also because of the national conference. National medical/scientific conferences usually issue press releases about stuff like this.

Be sure to check out the home page of the NEJM where a series of related articles is going to be published on Thursday- they have the full text downloadable to acrobat and though I wasn't able to print or save, I could read and look at all the figures.

There are two other interesting articles which are related- one validating the widely held understanding in the allergy community that PA has been increasing in frequency. This is important because now there is a statistical survey which supports this claim (which has been made by the medical community as well as people like us).

The other shows a link between peanut oil formulations in topical remedies and PA in eczemic infants.

It seems that the study group for the injectable serum DID include children, since at least one study participant who was interviewed by a major news agency was a fifteen year old girl. My major question about the selection of the study group was whether or not they took PA individuals who a) had never experienced anaphylaxis, or

b) had IgE levels out of the linear range of the test (like many of our children, who are simply rated as >100) Presumably not, since the study authors monitored blood IgE levels over the course of the study.

Finally, how typical were these people of PA? A threshold average of half a peanut seems pretty high given what we are accustomed to dealing with. (We have a daughter who is aerosol reactive)

Since the serum reduces free blood levels of IgE it seem likely that those whith the highest antibody levels may not stand to benefit much from this technology until a way is found to blunt/slow the production of IgE.

Anyway, I know that I certainly experienced a rush of emotions upon hearing the news that this really worked!!! I suddenly experienced an epiphany of what it would be like to just take away the FEAR in my life.

"I want to go to Sally's birthday party, Mom..." ME:"sure honey." "Can I go to camp with my friends?" US: "Why not?" "I really want to sell cookies this year..." ME: "When do we start?" "Can I spend the weekend with Grandma?" US: "Absolutely- have a great time."

I suddenly feel as though there is oxygen in the air again after so many years of crushing fear and anger at the non-PA universe for not allowing us to live normally.

There is NOTHING that I wouldn't pay to let my daughter go to school with other children, to eat an ice-cream cone, to go to a slumber party... to go to a baseball game with her father. (It's like one of those some-things-you-just-can't-buy Mastercard commercials run amok, I tell'ya! [img]http://uumor.pair.com/nutalle2/peanutallergy/biggrin.gif[/img] )

I am not usually so emotional- but the hope that this could one day be something other than a "suspended death sentence" for my beloved child is overwhelming. I have *hope* for her future rather than dread.

Shannon

On Mar 11, 2003

The story by the Associated Press confirms the participation of 15-year old Allison Rush. Jacqui Corba, 13, is scheduled for the third set of tests.

My dd is a level 5; we have our safety routine & our comfort level allows us to take her to see the AZ Diamondbacks baseball games, eat B-day cakes from two grocery chains, slumber parties, etc. I'm hopeful however, I can feel my comfort zone narrowing....maybe its a good thing that it will be caught up in a legal battle for a few years when the possibility of long term side effects could show up in the participants.

Robinlp, this is quoted from the NY Times:

"Xolair and if it is marketed, TNX-901 will be expensive....Medical experts said that the medication would cost more than $10,000 a year and that if a drug was approved for asthma, insurers were unlikely to pay for it for peanut allergies."

Read the full story by going to these links:

Associated Press>Top Stories News Headlines>Science>Hope for People w/deadly PA>Full Coverage>under news stories go to "Drug can limit PA, easing big fear by the NY Times.

The other stories listed have alittle more or alittle less than the others.

[This message has been edited by LisaMcDowell (edited March 12, 2003).]

On Mar 11, 2003

To LisaMcDowell & others - note that the TNX-901 drug and the asthma medication Xolair are identical or nearly identical. In fact, the NYTimes article yesterday indicated that some docs may prescribe Xolair for PA people. So if you're worried about side effects and other issues with the PA drug, keep an eye on Xolair when it hits the market.

On Mar 11, 2003

WILTON,

I have been wondering about Xolair, if it was similar to TNX. THanks.

Also, I saw an interview this morning with Dr. Hugh Sampson, and I believe he said that the study participants were 12 yrs and older.

This news blitz has also been wonderful to educate the public on the seriousness of PA. Everyone I know, has been calling me after reading about this!!

On Mar 11, 2003

Hi Wilton,

We must've been posting at the same time!

On Mar 12, 2003

LisaMcDowell- you mentioned that after the shot your dd may want to experiment with PB, from everything I have read PA people would still not be able to eat peanuts or peanutbutter, it would just be a treatment that would take the worry out of cross-contamination issues. It would be helpful for trace amount exsposures. But I'm pretty sure they said that a PA person would still not be able to eat peanut products. Please someone correct me if I am wrong! [img]http://uumor.pair.com/nutalle2/peanutallergy/smile.gif[/img] kcmom

On Mar 12, 2003

Hi KC Mom,

You read the article correctly, however I raised the issue in another topic titled: "Peanut Experimentation?".

Sometimes, you never know what kids will do. Peer pressure can be very strong to make one feel like they have to "fit in".

On Mar 12, 2003

Hi all,

I tried to do a little research on Xolair and TNX-901 for Wilton. Please see my comments on the Research board under "PA vaccine."

Troy

On Mar 12, 2003

Hello LisaMcDowell, I'm sorry didn't realize you had another topic on that!! [img]http://uumor.pair.com/nutalle2/peanutallergy/smile.gif[/img] I know what you mean by peer pressure! That is scaring me for dd's future. I just hope she's strong enough to withstand it! [img]http://uumor.pair.com/nutalle2/peanutallergy/smile.gif[/img] kcmom

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