Our directory is intended as a resource for people with peanut and nut allergies. It contains foods, helpful products, and much more.
- What is a Peanut Allergy
- Foods to Avoid
- The Allergic Reaction
- Recognizing and Treating Anaphylaxis
- Epinephrine Auto-Injectors
- Medical ID Bracelets
- Support Groups
Peanut Free and Nut Free
Other Food Allergies
Researchers suspect genetic link to most common allergies
Researchers at Johns Hopkins' Children's Center and Institute of Genetic Medicine believe that a genetic aberration in TGF-beta signaling may be to blame for many, if not most, common allergies.
The team believes they have linked a faulty genetic pathway, already known for a role in connective tissue disorders, with several allergy types.
The report was published in Science Translational Medicine and outlines the research team's findings.
Studying a possible common link among several types of allergies
The team first noticed the possibility of a connection when studying patients with Loeys-Dietz syndrome, finding that these individuals had a higher than normal rate of allergies to go with their malady. This was already known of those who have Marfan syndrome, another genetic issue with TGF-beta signal aberrations. Putting them together, the team realized that this may be a common link for many types of allergies.
Research showed that the patients with moderate to severe allergic reactions were high in T-cell counts, a common issue for allergy sufferers and those with hyperactive immune systems. Patients with TGF-beta will also often have overactive immune systems. This is known to be a marker for those with allergic reactions to otherwise innocent substances.
"We have evidence that the same glitch in TGF-beta that is responsible for some of the clinical manifestations seen in Marfan and Loeys-Dietz diseases also lies behind the cascade of events that culminates in the development of conditions like asthma, food allergies and eczema," Pamela Frischmeyer-Guerrerio, MD, PhD, an immunologist at Johns Hopkins Children's Center, said in a statement.
You will find the study here on sciencemag.org.
Sign up for our newsletter and receive a free peanut-free snack guide.
Stay on top of your allergy with recipes, lifestyle tips and more.