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non-IGE mediated allergy?

6 replies [Last post]
By jeancbpugh on Wed, 12-14-05, 18:22

I've been wondering why my son could have a negative RAST, negative skin tests, and still have an anaphylactic reaction from the food challenge.

Could it be that the RAST measures the levels of IgE, and his allergy could be non-IgE mediated? But wouldn't the protein in the skin test make him react, even if it is a non-IgE mediated allergy?

I am so confused.

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Jean
mom to DS with peanut & watermelon allergies (PA neg RAST, neg skin test, positive food challenge)
other DS with pollen, animal, dust allergies

[This message has been edited by jeancbpugh (edited December 14, 2005).]

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By starlight on Wed, 12-14-05, 18:48

My general practitioner told me that food allergies are sometimes an IGA mediated response, therefore those tests can be unaccurate.

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By krasota on Wed, 12-14-05, 22:54

Have another RAST done. I imagine that his antibody levels dropped with years of stringent avoidance (it happens). After re-exposure, his body reacted the same way it used to. I imagine his RAST would show elevated levels of IgE specific antibodies now.

This is why food challenges are done. Some of us continuing producing the antibodies for years without exposure. Some do not. Of those who do not, some are still allergic and antibody production will resume upon exposure. And some are truly no longer allergic. It seems like a crapshoot, but aren't you glad you found out via a controlled challenge?

ygg

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By kkeene on Wed, 12-14-05, 23:23

[url="http://www.findarticles.com/p/articles/mi_m0ISW/is_246/ai_112728008"]http://www.findarticles.com/p/articles/mi_m0ISW/is_246/ai_112728008[/url]

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By jeancbpugh on Thu, 12-15-05, 00:39

Quote:Originally posted by krasota:
[b]Have another RAST done. I imagine that his antibody levels dropped with years of stringent avoidance (it happens). After re-exposure, his body reacted the same way it used to. I imagine his RAST would show elevated levels of IgE specific antibodies now.

This is why food challenges are done. Some of us continuing producing the antibodies for years without exposure. Some do not. Of those who do not, some are still allergic and antibody production will resume upon exposure. And some are truly no longer allergic. It seems like a crapshoot, but aren't you glad you found out via a controlled challenge?

ygg[/b]

Yes, better to find out in a medical building attached to a hospital rather than say in an airplane over an ocean.

He has always had negative RASTs. He had positive skin tests in the past.

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Jean
DS PA & watermelon allergic (9/2005 neg RAST peanut & watermelon; 9/2005 skin test neg peanut, positive watermelon; 12/2005 peanut food challenge=anaphylaxis
other DS with pollen, animal, dust allergies

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By jeancbpugh on Sat, 12-17-05, 04:05

Quote:Originally posted by kkeene:
[b] [url="http://www.findarticles.com/p/articles/mi_m0ISW/is_246/ai_112728008"]http://www.findarticles.com/p/articles/mi_m0ISW/is_246/ai_112728008[/url]

[/b]

Have you had the Elisa test done?

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By jeancbpugh on Sat, 12-17-05, 04:14

Quote:Originally posted by kkeene:
[b] [url="http://www.findarticles.com/p/articles/mi_m0ISW/is_246/ai_112728008"]http://www.findarticles.com/p/articles/mi_m0ISW/is_246/ai_112728008[/url]

[/b]

I'm trying to read and understand the whole article, but honestly it is making me feel like one dim bulb. Hard read.

------------------
Jean
DS PA & watermelon allergic (9/2005 neg RAST peanut & watermelon; 9/2005 skin test neg peanut, positive watermelon; 12/2005 peanut food challenge=anaphylaxis
other DS with pollen, animal, dust allergies

Groups: None

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